Resident Evil Requiem Chapter 5 Walkthrough

Chapter 5 reveals the truth behind the outbreak as the group descends into the underground research facility. The chapter is narrative-heavy and includes optional Blood Analyzer puzzles, a new wristband upgrade, and the major branching decision about Emily’s fate.

This guide covers the full Chapter 5 route, puzzle solutions, item locations, the Emily branching point, and how to reach the Elpis Laboratory.

Chapter 5 Objectives

• Explore the underground facility entrance and secure the elevator area.
• Solve the optional Blood Analyzer puzzles in the Blood Lab.
• Obtain the Level 3 Wristband.
• Protect Emily through the research wing (or face the consequences).
• Learn about Elena / Elpis and the experiments that created the outbreak.
• Reach the Elpis containment chamber and set up the final act.

Map and Key Locations

Location	What to Find	Notes
Underground Entrance	Ammo, herbs	Combat tutorial for advanced infected
Blood Lab	Blood Analyzer puzzles	Optional but highly rewarding
Locker Room	Level 3 Wristband	Opens secure research wing
Secure Research Wing	High-tier ammo, lore files	Requires Level 3 Wristband
Emily Branching Point	Story decision	Emily’s fate is determined here
Elpis Laboratory	Audio logs, final choice	Sets up Chapter 6

Step-by-Step Walkthrough

1. Underground Entrance

After the courtyard rendezvous, Leon and Grace descend into the facility through a hidden elevator. The underground area is heavily populated with advanced infected, including Crawlers, Blister-Borne Minions, and Howlers. The path is mostly linear, but there are several side rooms worth looting.

Move slowly and use the environment. Gas vents can be neutralized by shooting the valves, and explosive barrels can clear groups of enemies. Conserve powerful ammo for the final chapters.

2. Blood Lab and Analyzer Puzzles

The Blood Lab contains two optional Blood Analyzer puzzles. These are logic-grid challenges that unlock crafting recipes and supplies.

• Denatured Blood Puzzle: Click the central node. Reward: Handgun Ammo + Hemolytic Injector crafting recipe.
• Reversible Blood Puzzle: Follow the path Bottom-left → Middle → Top-right → 2nd from top. Reward: Steroids + crafting recipe.

These puzzles are optional but provide valuable crafting unlocks. On Hardcore, the extra healing recipe is especially useful.

3. Level 3 Wristband

The Level 3 Wristband is required to open the secure research wing. Find it in the locker room near the security checkpoint. This wristband also opens several optional storage rooms containing high-tier ammo, healing items, and a lore file about the facility’s security protocols.

4. Secure Research Wing

With the Level 3 Wristband, you can access the secure research wing. This area has the strongest enemies in the chapter but also the best rewards, including magnum ammo and a rare weapon upgrade. Make sure Emily is with you and keep her safe here; losing her in this section can lock the best ending.

5. Emily’s Fate

This is the major branching point of the chapter. If Emily was kept alive and protected in Chapters 2-4, she remains with the group. If she was harmed, separated, or left behind, she mutates and becomes a boss fight for Leon.

• If Emily survives: She helps open the final door to the Elpis Laboratory and remains a supportive character in the ending.
• If Emily transforms: Leon must fight Emily (Transformed). See the boss guide for full strategy.

6. The Elpis Laboratory

The final area of the chapter reveals Elena, also known as Elpis. Listen to the audio logs and read the research files to understand the experiments. The chapter ends with a choice that sets up the final act of the game.

The research files reveal that Elpis was the first successful test subject of the bioweapon program, and that the outbreak was a result of a containment breach during a power failure.

Boss Fight in Chapter 5

Boss	Trigger	Recommended Weapon	Notes
Emily Transformed	Emily harmed in earlier chapters	Requiem / Magnum	Fast, high-damage boss

Puzzles in Chapter 5

Puzzle	Location	Solution	Reward
Blood Analyzer: Denatured Blood	Blood Lab	Click central node	Handgun Ammo + recipe
Blood Analyzer: Reversible Blood	Blood Lab	Bottom-left → Middle → Top-right → 2nd from top	Steroids + recipe

Key Items and Collectibles

• Level 3 Wristband: Required for the secure research wing.
• Blood Analyzer Rewards: Crafting recipes for Hemolytic Injector and Steroids.
• Magnum Ammo: Found in the secure research wing storage room.
• Lore Files: Audio logs and research notes about Elpis and Elena.
• High-tier Healing Items: In the secure storage rooms.

Chapter 5 Tips

• The Blood Analyzer puzzles are optional but highly rewarding.
• If Emily is still alive, protect her in the research wing; losing her here locks the “Save Emily” ending.
• Stock up on healing and magnum ammo before the next chapter.
• Read the research files for lore on Elpis and the outbreak origin.
• Use explosive barrels to clear groups of advanced infected.
• Shoot gas valves to clear toxic clouds in the entrance area.

Next Chapter

Continue to Chapter 6: Final Hour for the endgame, final boss, and branching endings.

Chapter 5 FAQ

How long does Chapter 5 take? About 2 to 2.5 hours.

Where is the Level 3 Wristband? In the locker room near the security checkpoint.

What happens if Emily dies? If she was harmed earlier, she transforms into a boss. Otherwise, she survives and helps in the ending.

How do I solve the Blood Analyzer puzzles? Denatured Blood: click the central node. Reversible Blood: Bottom-left → Middle → Top-right → 2nd from top.

What do the rewards unlock? Crafting recipes for powerful healing items and ammo.

Who is Elena / Elpis? The central test subject of the Rhodes Hill experiments. The audio logs and files reveal the full story.

Can I skip the Blood Analyzer puzzles? Yes, but the rewards are highly recommended.

What determines whether Emily transforms? Her state across Chapters 2-4. Protect her in every chapter to keep her alive.