Story & Lore Database
Resident Evil Requiem Story & Lore Guide
Read the complete Resident Evil Requiem story explained. Discover the lore, timeline, characters, major events, and how every ending connects to the Rhodes Hill Care Center outbreak.
Resident Evil Requiem is set at the Rhodes Hill Care Center, a remote medical facility that becomes the epicenter of a deadly bioweapon outbreak. The story follows Grace Ashcroft, who wakes up inside the facility with no memory of her arrival. As she explores the overrun building, she meets Emily, a young survivor with the ability to read Braille, and Leon S. Kennedy, a veteran DSO agent investigating the incident.
Together, the survivors uncover a conspiracy involving secret experiments by The Connections, the antiviral cure known as Elpis, and antagonist Victor Gideon's plan. The narrative combines survival horror gameplay with a character-driven mystery.
This Resident Evil Requiem story wiki explains the plot, timeline, major events, characters, and all endings in one place.
Official wording. Plot summaries and terminology on this page follow the official English release — in-game script and cutscenes. Where fan translations differ, official English wording takes precedence.
Rhodes Hill operates as a psychiatric long-term care facility, while The Connections run secret experiments on patients — creating the conditions for the outbreak.
Grace Ashcroft, an FBI intelligence analyst, investigates the Care Center where her mother Alyssa Ashcroft was murdered years earlier.
Grace finds Emily — a blind girl and clone created by The Connections ("Subject 171") — in the isolation ward. Emily can read Braille and is key to the Star Quartz puzzle.
Leon S. Kennedy, a veteran DSO agent, investigates the outbreak and joins forces with Grace. His campaign is third-person action to Grace's first-person horror.
Grace gathers the Moon, Sun, and Star Quartz to open the way out of the Care Center. During the helicopter escape, the crash kills Reed and severely injures Emily — a scripted story beat.
Severely injured, Emily mutates and attacks Grace. Leon steps in and shoots her non-fatally.
Elpis — Oswell E. Spencer's antiviral cure — becomes the final decision: release it (password HOPE) for the true ending, or destroy it for the alternate ending.
True ending: Leon is cured, Emily is cured and adopted by Grace, and Raccoon City Syndrome victims are cured. Alternate: the ARK is destroyed, Leon dies, Emily is left in her cocoon.
Major Events
A bioweapon experiment at the Rhodes Hill Care Center goes wrong, turning patients and staff into hostile creatures. The outbreak traps Grace and the others inside.
Grace discovers Emily in the isolation ward. Their bond becomes the emotional core of the story, and Emily's Braille reading is essential to the Star Quartz puzzle.
Leon S. Kennedy arrives to contain the situation. His combat experience complements Grace's investigation and puzzle-solving skills.
Grace gathers the three Quartz and opens the way out of the Care Center — but the helicopter escape ends in a crash that leaves Emily severely injured.
The player decides whether to release or destroy Elpis, Spencer's antiviral cure. This single choice determines the ending: Hope or Destruction.
Main Characters
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Frequently Asked Questions
What is the story of Resident Evil Requiem?
Resident Evil Requiem follows Grace Ashcroft, who wakes up in the Rhodes Hill Care Center during a bioweapon outbreak. She teams up with Emily, a young survivor, and Leon S. Kennedy to uncover the truth behind Elpis and the experiments that caused the incident.
Who is Elpis in Resident Evil Requiem?
Elpis is an antiviral cure created by Oswell E. Spencer — not a character. Releasing or destroying it at the ARK is the game's final choice and decides which of the two endings you see.
What happened at Rhodes Hill Care Center?
Rhodes Hill Care Center was the site of secret experiments that led to a bioweapon outbreak. The facility becomes overrun, and the survivors must navigate the facility while uncovering the conspiracy behind the incident.
How many endings does Resident Evil Requiem have?
Resident Evil Requiem has exactly two endings, decided by one final choice: release Elpis (the true "Hope" ending) or destroy it (the alternate "Destruction" ending).
Is Resident Evil Requiem connected to the main Resident Evil series?
Resident Evil Requiem features Leon S. Kennedy, a recurring character from the main series. The story is a self-contained adventure that expands on the Resident Evil lore through new characters and a new outbreak location.
About This Story Guide
This Resident Evil Requiem story and lore guide is part of the Requiem Guide knowledge graph. We cover the plot, characters, timeline, and endings to help players understand the narrative and answer common AI search questions.
For gameplay help, visit the Boss Guides, Weapons Database, and Walkthrough. For character details, see the Characters Database.